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High-throughput high-content detection of genetic modifiers of neurodegeneration in human stem cell derived neurons

Yao, Y;Sun, X;Cui, X;Lu, B;

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Mesenchymal stem cells (MSCs) have been repeatedly shown to be able to repair bone defects. The aim of this study was to characterize the osteogenic differentiation of miniature pig MSCs and markers of this differentiation in vitro. Flow-cytometrically characterized MSCs were seeded on cultivation plastic (collagen I and vitronectin coated/uncoated)…
Juhasova, J;Juhas, Š;Klima, J;Strnadel, J;Holubova, M;

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Mitochondria-targeted chromanol inhibits breast cancer cell energy metabolism and promotes cell death

Cheng, G;Zielonka, J;McAllister, DM;Mackinnon Jr, AC;

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GDNF augments proliferation and reduces apoptosis of murine retinal progenitor cells

RESULTS: : RPCs exhibited exponential growth in either EGF or EGF+GDNF, with the latter condition showing a measurable advantage. Live-cell monitoring of both conditions revealed that initial aggregates formed as early as 5.5 hr from collision and adherence of dissociated RPCs, as opposed to clonal proliferation. Spheres subsequently enlarged in…
Wang, J;Yang, J;Klassen, H;

Investigative Ophthalmology & Visual Science
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XV World Congress on Cancers of the Skin 2014-3rd-6th September 2014, Edinburgh, UK

Insulin-like growth factor II mRNA-binding protein 3 (IMP-3)is an oncoprotein important in cell growth and migration infetal development. Many studies have found IMP-3 expressionin malignant tumours but not in adjacent benign tissues. Luet al. reported that IMP-3 expression in dysplastic cervicallesions is closely associated with their invasive potential, andwith more…
Aljefri, K;Ally, M;Fassihi, H;Lewis, F;Attard, N;Mellerio, J;

British Journal of Dermatology
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German Stem Cell Network eV Annual Magazine 2013/14© 2014 GSCN

Besser, D;Papra, U;Graf, P;Finnis, T;Birnie, J;

Stem Cell Research
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Cell morphological changes combined with biochemical assays for assessment of apoptosis and apoptosis reversal

It has recently been reported that apoptosis induced in cancer cells can be reversed if a sub-maximal apoptotic stimulus isremoved. To investigate the effect of apoptosis reversal on cell morphological changes, we induced apoptosis in braintumor cells as well as normal glial cells, specifically astrocytes, using the apoptosis inducer staurosporine…
Joshi, C;Karumuri, B;Newman, JJ;

Current Microscopy Contributions to Advances in Science and Technology
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Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

The Hedgehog (Hh) signaling pathway plays an important role in embryonic patterning and development of many tissues and organs as well as in maintaining and repairing mature tissues in adults. Uncontrolled activation of the Hh-Gli pathway has been implicated in developmental abnormalities as well as in several cancers, including brain…
Malatesta, M;Steinhauer, C;Mohammad, F;Pandey, DP;

Cancer research
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RhoA and Rac1 play independent roles in lysophosphatidic acid-induced ovarian cancer chemotaxis

Lysophosphatidic acid (LPA), which is a bioactive phospholipid existing at high level in ascites and plasma of ovarian cancer patients, is known to be involved in cell survival, proliferation, adhesion, and migration. Small guanosine triphosphatases (GTPases) such as RhoA and Rac1 are intracellular signaling molecules which affect morphology and chemotactic…
Suh, PG;Cho, YK;

Integrative Biology
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Peroxisome proliferator-activated receptor-γ activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition

Reka, AK;Kurapati, H;Narala, VR;Bommer, G;

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